Table 3. Identified genes in A. xylosoxidans NH44784-1996 involved in antibiotic resistance.
| Product | No. of genes | Gene name/abbrev. | A8 | PAO1 | J2315 | K-12 |
|---|---|---|---|---|---|---|
| β-lactamases | ||||||
| Beta-lactamase class C and other penicillin binding proteins | 2 | - | X | X | X | - |
| Beta-lactamase | 4 | - | X | X | X | X |
| Beta-lactamase class D (OXA-114) | 1 | OXA-114 | - | - | X | - |
| Metallo-Beta-lactamase superfamily protein | 1 | - | - | X | X | - |
| Metallo-Beta-lactamase family protein, putative | 1 | - | X | X | X | - |
| Metallo-Beta-lactamase family protein, RNA-specific | 1 | - | X | X | X | - |
| Penicillin-binding protein 2 (PBP-2) | 1 | - | X | X | X | X |
| Penicillin-insensitive transglycosylase (EC 2.4.2.-) & transpeptidase PBP-1C | 1 | - | X | - | - | X |
| Aminoglycoside modifying enzyme | ||||||
| Aminoglycoside N3-acetyltransferase | 1 | - | - | - | - | - |
| Predicted aminoglycoside phosphotransferase | 1 | - | X | - | - | - |
| Aminoglycoside 3'-phosphotransferase (Kanamycin kinase, type VI) (Neomycin-kanamycin phosphotransferase type VI) (APH(3')VI) | 1 | - | - | - | - | - |
| Efflux pump | ||||||
| Inner membrane component of tripartite multidrug resistance system | 4 | - | X | X | X | X |
| Membrane fusion component of tripartite multidrug resistance system | 4 | - | X | X | X | X |
| Outer membrane component of tripartite multidrug resistance system | 6 | - | X | X | X | X |
| Acriflavin resistance protein | 1 | - | X | X | X | X |
| Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) | 1 | MacB | X | - | X | X |
| Macrolide-specific efflux protein MacA | 1 | MacA | X | - | X | X |
| Multidrug-efflux transporter, major facilitator superfamily (MFS) (TC 2.A.1) | 1 | - | - | - | - | X |
| Transcription repressor of multidrug efflux pump acrAB operon, TetR (AcrR) family | 1 | TetR | X | - | - | X |
| Type I secretion outer membrane protein, TolC precursor | 1 | TolC | X | X | - | X |
| Probable transcription regulator protein of MDR efflux pump cluster | 1 | - | X | - | - | - |
| RND multidrug efflux transporter; Acriflavin resistance protein | 4 | - | X | - | - | - |
| RND efflux system, outer membrane lipoprotein, NodT family | 2 | NodT | X | X | X | - |
| RND efflux system, membrane fusion protein CmeA | 5 | CmeA, AxyA | X | X | X | - |
| RND efflux system, inner membrane transporter CmeB | 5 | CmeB, AxyB | X | X | X | X |
| RND efflux system, outer membrane lipoprotein CmeC | 7 | CmeC, AxyM | X | X | X | - |
| Tetracycline efflux protein TetA | 1 | TetA | X | - | - | - |
| Transcriptional regulator | ||||||
| TetR family | 34 | TetR | X | X | X | X |
| MAR locus | ||||||
| Multiple antibiotic resistance protein MarC | 1 | MarC | X | X | X | X |
An X refers to the presence of these genes in A. xylosoxidans A8, P. aeruginosa PAO1, B. cenocepacia J2315 or E. coli K-12