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. Author manuscript; available in PMC: 2013 Jul 22.
Published in final edited form as: Results Probl Cell Differ. 2009;48:289–326. doi: 10.1007/400_2009_4

Fig. 1.

Fig. 1

SMN1 exon boundaries and protein domain structure. Top: SMN1 is encoded by 9 exons. Coding regions are indicated in cyan and untranslated regions in purple. Bottom: Domains required for oligomerization of SMN are indicated as black bars. Other regions of interest are the Tudor domain (red), poly-proline regions (green), the YG box (orange), and the cytoplasmic targeting motif (black). Point mutations identified in SMN1 genes of SMA patients are indicated below (Wirth 2000; Alias et al. 2008)