Table 1.

SMN-associated proteins, functions, and motifs^a

SMN associated protein	Function	Motifsb	References
SMN-Gemin complex
Gemin1/SMN	snRNP assembly	Tudor, Y/G box	Liu et al. (1997)
Gemin2/SIP1	snRNP assembly	–	Liu et al. (1997)
Gemin3/DDX20/DP103	snRNP assembly	DEXDc, HELICc	Charroux et al. (1999); Meister et al. (2000)
Gemin4/GIP1	snRNP assembly	Leu zipper	Charroux et al. (2000); Meister et al. (2000)
Gemin5/p175	snRNP assembly	WD40 repeats	Gubitz et al. (2002)
Gemin6	snRNP assembly	–	Pellizzoni et al. (2002a)
Gemin7/SIP3	snRNP assembly	RG-rich	Baccon et al. (2002)
Gemin8	snRNP assembly	–	Carissimi et al. (2006)
unrip	snRNP assembly	WD40 repeats	Meister et al. (2001)
snRNP core proteins
Sm proteins/Sm B/B–, D1–3,E,F,G	snRNP assembly	Sm domain, RG rich	Liu et al. (1997); Friesen and Dreyfuss (2000)
Sm-like proteins/Lsm 10,11	snRNP assembly	Sm domain, RG rich	Friesen and Dreyfuss (2000); Brahms et al. (2001)
snoRNP core proteins
Fibrillarin/FBL	snoRNP assembly	RGG box, RNP-2	Liu and Dreyfuss (1996); Jones et al. (2001); Pellizzoni et al. (2001a)
GAR1/Nola1	snoRNP assembly	RGG box	Pellizzoni et al. (2001a)
snRNP import
Snurportin and importin β	Nuclear import of snRNPs	HEAT repeat	Narayanan et al. (2002)
TGSI (trimethylguanosine synth. 1)	Nuclear import of snRNPs	–	Mouaikel et al. (2003)
Cajal body/coiled body
Coilin/p80	Recruitment of SMN to Cajal bodies	–	Hebert et al. (2001)
Transcription
mSin3A	Transcriptional regulation	PAH, HDAC interact	Zou et al. (2004)
EWS (Ewing Sarcoma)	Transcriptional regulation	RGG box	Young et al. (2003)
Viral proteins
Papilloma virus E2	Transcriptional regulation	–	Strasswimmer et al. (1999)
Epstein-Barr virus nuclear antigen	Transcriptional regulation	–	Barth et al. (2003)
Minute virus NS1 and NS2	Viral replication and transcriptional regulation	–	Young et al. (2002b)
Actin metabolism
Profilin	Control of actin dynamics	–	Giesemann et al. (1999b)
T-Plastin/PLS3	Actin bundling	EFh, CH	Oprea et al. (2008)
Apoptosis
p53	Apoptosis	–	Young et al. (2002a)
Bcl-2	Antiapoptosis	BH4, BCL	Iwahashi et al. (1997)
RNA metabolism
hnRNP U	RNA metabolism	SAP, SPRY, RGG	Liu and Dreyfuss (1996)
hnRNP Q and R	RNA metabolism	RRM, RGG	Mourelatos et al. (2001); Rossoll et al. (2002)
FUSE-binding protein/FBP	RNA metabolism	KH	Williams et al. (2000b)
KSRP/FBP2/ZBP2/MARTA1	RNA metabolism	KH	Tadesse et al. (2008)
FMRP	RNA metabolism	KH, Agenet	Piazzon et al. (2008)
U1A	pre-mRNA splicing	RRM	Liu et al. (1997)
Galectin 1 and 3/LGALS1	pre-mRNA splicing	GLECT	Park et al. (2001)
RNA helicase A	Transcription	DSRM, DEXDc, HELICc	Pellizzoni et al. (2001b)
RNA polymerase II	Transcription	–	Pellizzoni et al. (2001a)
Rpp20 (Ribonuclease P 20 kDa subunit)	tRNA and rRNA metabolism	–	Hua and Zhou (2004a)
Nucleolin and B23	rRNA metabolism	RRM, RGG-box	Lefebvre et al. (2002)
ISG20 (Interferon stimul. gene 20)	Degradation of ssRNA	EXOIII	Espert et al. (2006)
TIAR (TIA-1-related protein)	Stress granule formation	RRM	Hua and Zhou (2004b)
TDP-43 (TAR DNA-binding protein)	mRNA splicing and transcription	RRM	Wang et al. (2002)
NFAR-1/2/nuclear factor associated with dsRNA	RNA metabolism	DZF, DSRM	Saunders et al. (2001)
Others
OSF (osteoclast-stimulating factor)	Src-related signaling	SH3, ANK	Kurihara et al. (2001)
USP9X (Ubiquitin-specific protease 9)	Deubiquitylating enzyme	–	Trinkle-Mulcahy et al. (2008)
PPP4 (protein phosphatase 4)	Ser/Thr protein phosphatase	PP2Ac	Carnegie et al. (2003)
FGF-2 (fibroblast growth factor 2)	Growth factor	FGF	Claus et al. (2003)
hsc70 (heat shock cognate prot. 70)	Protein folding/trafficking	–	Meister et al. (2001)
ZPR1 (zinc-finger protein 1)	Protein translation?	Zpr1	Gangwani et al. (2001)
BAT3/HLA-B assoc. transcript 3c	Apoptosis/regulation of p53	UBQ domain	Stelzl et al. (2005)
UNC119/HRG4c	Photoreceptor synaptic protein	GMP-PDE delta	Stelzl et al. (2005)
RIF1 (receptor interact. factor 1)c	Transcriptional repressor	–	Stelzl et al. (2005)
GDF9 (growth diff. factor 9)c	Growth factor	TGFB	Stelzl et al. (2005)
COPS6 (COP9 signalosome subunit 6)c	Regulation of ubiquitin ligases	JAB/MPN	Stelzl et al. (2005)
Leukocyte receptor cluster LRC member 8c	–	SAC3/GANP	Rual et al. (2005)
FLJ10204/C8orf32c	–	–	Rual et al. (2005)

^aMeister et al. (2002); Peri et al. (2003); Stark et al. (2006); Wirth et al. (2006)

^bBased on Schultz et al. (1998)

^cInteraction partners identified in high throughput screens may have not been confirmed by independent methods