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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Cancer Res. 2013 Apr 10;73(14):4362–4371. doi: 10.1158/0008-5472.CAN-12-3154

Figure 4. Ectopic expression of HsXpf-Ercc1 or HsMus81-Eme1 suppresses the lethality in XPF−/− cells.

Figure 4

(A) Growth curve after addition of TAM to the indicated cells at time zero. + HsXPF alone and +HsXPF-ERCC1 represent XPF−/−GdXPF-loxP cells expressing HsXpf alone and XPF−/−GdXPF-loxP cells expressing HsXpf-Ercc1, respectively. (B) Spontaneous chromosomal aberrations in the indicated cells were measured as described in Figure 1D. (C) Growth curve after addition of TAM to the indicated cells at time zero. +HsMUS81-EME1 represents XPF−/−GdXPF-loxP cells expressing HsMus81-Eme1. (D) Spontaneous chromosomal aberrations in the indicated cells were measured as described in Figure 1D.