Table 3.
Associations Between Postdiagnostic Red and Processed Meat Intake and Mortality Among 1,186 Patients With CRC (663 men and 523 women) in the Cancer Prevention Study II Nutrition Cohort
| Outcome | Postdiagnostic Red and Processed Meat Intake (servings/week)* |
Continuous Meat Intake (servings/week) |
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Q1† |
Q2 |
Q3 |
Q4 |
Ptrend‡ | |||||||||||||||
| Total Deaths | Person-Years | RR | 95% CI | Total Deaths | Person-Years | RR | 95% CI | Total Deaths | Person-Years | RR | 95% CI | Total Deaths | Person-Years | RR | 95% CI | RR | 95% CI | ||
| All-cause mortality | 112 | 2,140 | 131 | 2,423 | 119 | 2,198 | 110 | 2,213 | |||||||||||
| Base model§ | 1.00 | — | 1.13 | 0.87 to 1.47 | 1.23 | 0.94 to 1.61 | 1.03 | 0.78 to 1.36 | .97 | 1.00 | 0.97 to 1.03 | ||||||||
| Multivariable model 1‖ | 1.00 | — | 1.13 | 0.87 to 1.47 | 1.25 | 0.94 to 1.64 | 1.02 | 0.76 to 1.38 | .90 | 1.00 | 0.97 to 1.03 | ||||||||
| Multivariable model 2¶ | 1.00 | — | 1.24 | 0.95 to 1.62 | 1.26 | 0.95 to 1.67 | 1.09 | 0.81 to 1.48 | .91 | 1.00 | 0.97 to 1.03 | ||||||||
| Multivariable model 3# | 1.00 | — | 1.17 | 0.89 to 1.55 | 1.13 | 0.84 to 1.52 | 0.94 | 0.68 to 1.30 | .36 | 0.98 | 0.95 to 1.01 | ||||||||
| CRC mortality | 27 | 2,140 | 42 | 2,423 | 35 | 2,198 | 42 | 2,213 | |||||||||||
| Base model§ | 1.00 | — | 1.42 | 0.86 to 2.35 | 1.34 | 0.80 to 2.25 | 1.55 | 0.94 to 2.57 | .11 | 1.03 | 0.98 to 1.08 | ||||||||
| Multivariable model 1‖ | 1.00 | — | 1.31 | 0.79 to 2.17 | 1.12 | 0.66 to 1.91 | 1.28 | 0.74 to 2.21 | .46 | 1.01 | 0.95 to 1.06 | ||||||||
| Multivariable model 2¶ | 1.00 | — | 1.38 | 0.83 to 2.30 | 1.09 | 0.63 to 1.86 | 1.34 | 0.77 to 2.33 | .42 | 1.00 | 0.95 to 1.06 | ||||||||
| Multivariable model 3# | 1.00 | — | 1.28 | 0.76 to 2.15 | 0.93 | 0.53 to 1.64 | 1.10 | 0.61 to 1.98 | .91 | 0.98 | 0.92 to 1.04 | ||||||||
| Cardiovascular disease mortality | 31 | 2,140 | 30 | 2,423 | 27 | 2,198 | 22 | 2,213 | |||||||||||
| Base model§ | 1.00 | — | 1.01 | 0.60 to 1.70 | 1.09 | 0.63 to 1.88 | 0.88 | 0.50 to 1.57 | .50 | 0.99 | 0.93 to 1.05 | ||||||||
| Multivariable model 1‖ | 1.00 | — | 1.06 | 0.62 to 1.81 | 1.18 | 0.67 to 2.08 | 0.88 | 0.47 to 1.64 | .48 | 0.98 | 0.92 to 1.05 | ||||||||
| Multivariable model 2¶ | 1.00 | — | 1.17 | 0.68 to 2.02 | 1.21 | 0.68 to 2.16 | 0.96 | 0.51 to 1.83 | .63 | 0.99 | 0.92 to 1.05 | ||||||||
| Multivariable model 3# | 1.00 | — | 1.09 | 0.62 to 1.91 | 1.10 | 0.60 to 2.02 | 0.86 | 0.43 to 1.71 | .42 | 0.97 | 0.91 to 1.05 | ||||||||
| All other causes of mortality | 54 | 2,140 | 59 | 2,423 | 57 | 2,198 | 46 | 2,213 | |||||||||||
| Base model§ | 1.00 | — | 1.05 | 0.72 to 1.53 | 1.26 | 0.86 to 1.86 | 0.84 | 0.56 to 1.27 | .39 | 0.99 | 0.95 to 1.03 | ||||||||
| Multivariable model 1‖ | 1.00 | — | 1.11 | 0.75 to 1.62 | 1.42 | 0.95 to 2.11 | 0.94 | 0.60 to 1.46 | .76 | 1.00 | 0.96 to 1.04 | ||||||||
| Multivariable model 2¶ | 1.00 | — | 1.21 | 0.82 to 1.78 | 1.44 | 0.96 to 2.15 | 0.98 | 0.63 to 1.53 | .79 | 1.00 | 0.96 to 1.04 | ||||||||
| Multivariable model 3# | 1.00 | — | 1.18 | 0.79 to 1.77 | 1.33 | 0.87 to 2.04 | 0.87 | 0.54 to 1.41 | .38 | 0.98 | 0.94 to 1.03 | ||||||||
Abbreviations: CRC, colorectal cancer; Q, quartile; RR, relative risk.
Quartiles in men and women vary based on which survey year postdiagnostic meat intake is from.
Reference quartile.
Ptrend calculated by using the median meat intake in each quartile, specific to sex, and vary based on which survey year post-diagnostic meat intake is from.
Base model adjusted for age at diagnosis and sex.
Multivariable model 1 adjusted for age at diagnosis, sex, tumor stage at diagnosis, and postdiagnostic energy intake (sex-specific quartiles).
Multivariable model 2 additionally adjusted for weight change between 1992 prediagnostic and postdiagnostic questionnaires.
Multivariable model 3 additionally adjusted for 1992 prediagnostic meat intake (sex-specific quartiles).