Table 1.
Prematching Characteristics
| Variable | Control (n = 334) | ILD-rFVIIa (n = 77) | p Value |
|---|---|---|---|
| Age (years) | 59 (46–67) | 59 (48–70) | 0.24 |
| Male sex | 233 (70%) | 52 (68%) | 0.70 |
| Race | 0.009 | ||
| White | 256 (77%) | 51 (66%) | |
| Black | 66 (20%) | 17 (22%) | |
| Other | 12 (4%) | 9 (12%) | |
| Height (cm) | 175 (168–183) | 175 (165–183) | 0.23 |
| Weight (kg) | 86 (73–99) | 76 (65–92) | 0.002 |
| Body mass index (kg/m2) | 27.6 (24.4–31.7) | 26.4 (21.6–29.8) | 0.005 |
| Preoperative anticoagulants | |||
| Aspirin | 145 (43%) | 34 (44%) | 0.91 |
| Clopidogrel | 16 (5%) | 4 (5%) | 0.88 |
| Warfarin | 41 (12%) | 16 (21%) | 0.05 |
| Baseline laboratory values | |||
| Hemoglobin (g/dL) | 13.6 (12.2–14.8) | 12.8 (11.4–13.7) | 0.0006 |
| Platelets (109 cells/L) | 213 (179–253) | 180 (163–226) | 0.001 |
| International normalized ratio | 1.0 (1.0–1.1) | 1.0(1.0–1.1) | 0.29 |
| Partial thromboplastin time (sec) | 30.5 (28.4–33.6) | 31.1 (27.9–33.1) | 0.89 |
| Creatinine (mg/dL) | 1.0 (0.9–1.2) | 1.0 (0.8–1.2) | 0.83 |
| Case status | 0.0004 | ||
| Elective | 259 (78%) | 44 (57%) | |
| Urgent | 39 (12%) | 16 (21%) | |
| Emergent | 36 (11%) | 17 (22%) | |
| ASA class | 0.009 | ||
| II | 5 (2%) | 0 | |
| III | 203 (61%) | 36 (47%) | |
| IV | 126 (38%) | 41 (53%) | |
| Redo sternotomy | 59 (18%) | 24 (31%) | 0.008 |
| Principal procedure | 0.93 | ||
| Root or ascending replacement, or both | 63 (19%) | 16 (21%) | |
| Root or ascending, or both, + hemiarch | 228 (68%) | 48 (62%) | |
| Root or ascending, or both + total arch | 16 (5%) | 9 (12%) | |
| Descending or thoracoabdominal | 27 (8%) | 4 (5%) | |
| Concomitant procedure | 92 (28%) | 31 (40%) | 0.03 |
| Deep hypothermic circulatory arrest | 263 (79%) | 62 (81%) | 0.73 |
| Cardiopulmonary bypass time (min) | 204 (183–232) | 222 (195–264) | 0.0005 |
| Nadir hemoglobin on bypass (g/dL) | 7.8 (7.0–8.7) | 7.3 (6.7–8.0) | 0.0003 |
| Total intraoperative transfusions | |||
| Red blood cells (mL) | 700 (0–1,400) | 1400 (700–2100) | <0.0001 |
| Fresh frozen plasma (mL) | 1000 (540–1,750) | 2000 (1,500–2,750) | <0.0001 |
| Pooled platelet concentrates (mL) | 489 (300–600) | 800 (600–863) | <0.0001 |
| Cryoprecipitate (mL) | 0 (0–0) | 100 (0–100) | <0.0001 |
| Cell saving device return (mL) | 500 (250–700) | 750 (500–1,200) | <0.0001 |
Values expressed as median (interquartile range) or number (percent).
ASA = American Society of Anesthesiologists; ILD-rFVIIa = intraoperative low-dose recombinant activated factor VII.