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. 2013 Jul 22;202(2):295–309. doi: 10.1083/jcb.201210099

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© 2013 Park et al.

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Figure 3. — K243R/+ MEFs exhibit aneuploidy with a high incidence of PMSCS. (A) The percentage of cells displaying the indicated number of chromosomes. The results are from three and five different WT and K243R/+ MEFs, respectively. (bottom) The table summarizes the analysis of the chromosome numbers in the histogram. (B) Representative images of the metaphase chromosome spreads. (C) Incidence of PMSCS. MEFs were treated with MG132 for 2 h or left untreated, and chromosome spreads were analyzed (WT, n = 96; WT treated with MG132, n = 51; K243R/+, n = 91; K243R/+ treated with MG132, n = 70; *, P = 0.04). Cells containing more than one chromosome featuring PMSCS were scored. (D) Two examples of SKY analysis of the K243R/+ MEFs cultured for 27 passages are shown.