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. 2013 Jul 22;202(2):295–309. doi: 10.1083/jcb.201210099

Table 1.

Tumor spectrum and analysis

Tumor types BubR1K243R/+ (n = 121) BubR1+/+ (n = 41)
Malignant tumors 28 (23.1%) 2 (4.8%)
Malignant solid tumors 13 (10.7%) 1 (2.4%)
Hepatocellular carcinoma 6 (5.0%)
Sarcomaa 4 (3.3%) 1 (2.4%)
Adenocarcinomab 2 (1.7%)
Other cancerc 1 (0.8%)
Hematologic malignancies 15 (12.4%) 1(2.4%)
Megakaryocyte leukemia 1 (0.8%)
B cell lymphoma 11 (9.1%) 1 (2.4%)
Metastatic lymphoma/leukemia 3 (2.5%)
Benign tumorsd 18 (14.9%)
Total tumor incidence 46 (38.0%) 2 (4.8%)
a

Sarcomas included smooth muscle sarcoma (n = 2), endometrial stromal sarcoma (n = 1), and angiosarcoma (n = 1) in K243R/+ mice. A single fibrosarcoma was found in the WT.

b

Adenocarcinomas included lung adenocarcinoma (n = 1) and rectal adenocarcinoma (n = 1) in K243R/+.

c

Other cancer included skin cancer.

d

Benign tumors included simple cysts in the genital tract (n = 10), hemangioma (n = 5), epidermal cyst (n = 1), acrochordon (n = 1), and mesenchymal fibroma (n = 1).