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. 2013 Jul 22;202(2):211–219. doi: 10.1083/jcb.201212060

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© 2013 Lin et al.

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Figure 3. — CEP120 cooperates with CPAP to promote centriole elongation and both hSAS-6 and STIL are required for CEP120-induced centriole elongation. (A–C) CPAP-Myc– (B) and CEP120-Myc (C)–inducible cells were treated as shown in A and analyzed by confocal fluorescence microscopy. The percentages of CPAP-Myc– or CEP120-Myc–induced elongated or nonelongated procentrioles formed after siCEP120 (B) or siCPAP (C) treatment are shown. (D–H) Depletion of hSAS-6 or STIL inhibits CEP120-induced centriole elongation. CEP120-Myc–inducible cells were transfected with siControl, sihSAS-6 (E and F), or siSTIL (G and H) as shown in D. Histograms illustrating the percentages of elongated or nonelongated centrioles induced by CEP120 overexpression in sihSAS-6– (E) or siSTIL-treated cells (G). Error bars represent means ± SD of 100 cells from three independent experiments.