Table 1.

Comparison of state-to-state frequency and growth/shrinkage rate between control and MoesinT₅₅₉D- and MoesinK_212,213M,T₅₅₉D-expressing cells

State to state and rates	Control	MoesinT559D	MoesinK211,212M,T559D
G → S
(ns−1)	0.0114 (44)	0.0055 (13)	0.0125 (20)
(ns−1)	0.0085–0.0148	0.0031–0.0091	0.0079–0.0184
		P = 0.0139a	P = 0.714
G → P
(ns−1)	0.0569 (220)	0.062 (146)	0.0579 (93)
(ns−1)	0.0527–0.0609	0.0569–0.0665	0.0525–0.0635
		P = 0.134	P = 0.783
S → G
(ns−1)	0.0110 (37)	0.0142 (22)	0.0062 (12)
(ns−1)	0.0079–0.0147	0.0092–0.0203	0.0034–0.0104
		P = 0.298	P = 0.0788
S → P
(ns−1)	0.0564 (190)	0.0544 (84)	0.0543 (105)
(ns−1)	0.0521–0.0605	0.0481–0.0602	0.0483–0.0595
		P = 0.589	P = 0.566
P → G
(ns−1)	0.0271 (148)	0.0177 (85)	0.0192 (54)
(ns−1)	0.0229–0.0318	0.0139–0.0218	0.0143–0.0248
		P = 0.0047b	P = 0.037a
P → S
(ns−1)	0.0216 (118)	0.0121 (58)	0.0214 (60)
(ns−1)	0.018–0.0256	0.009–0.0158	0.0161–0.0275
		P = 0.0014c	P = 0.9401
Pause state
(%)	67.3 (3,421)	78.2 (3,235)	69.6 (1,863)
(%)	66.0–68.6	76.9–79.4	67.8–71.3
Shrinkage state
(%)	14.8 (752)	8.3 (343)	15.8 (422)
(%)	13.8–15.8	7.5–9.2	14.4–17.2
Growth state
(%)	17.9 (912)	13.5 (558)	14.6 (391)
(%)	16.9–19.0	12.5–14.6	13.3–16.0
Growth rate
(µm/min)	2.68	2.39	2.55
(µm/min)	±0.052	±0.063	±0.078
		P = 4.3.10−4c	P=0.141
Shrinkage rate
(µm/min)	2.61	2.54	2.46
(µm/min)	±0.058	±0.09	±0.078
		P = 0.552	P = 0.159

Bold numbers denote statistically significant different values from controls. Numbers in parentheses indicate the event count. Intervals indicate 95% confidence. Statistical significance for sate-to-state transition frequencies was determined using a two-tailed permutation test with 10,000 resamples. For growth and shrinkage rates, a two-sample t test was used to determine statistical significance (±SEM).

^aStatistically different from control if P < 0.05.

^bP < 0.01.

^cP < 0.001.