Figure 3.
Attenuation of sodium nitroprusside (SNP)-induced vasodilation of radial uteroplacental arteries by PPARγ inhibition during rat pregnancy. Representative tracings showing dilatation of uteroplacental arteries from control (A) and GW9662-treated (B) pregnant rats induced by a cumulative application of SNP. Dotted lines indicate the maximal arterial diameters (Dmax) in the presence of papaverine and diltiazem. (C) Graph summarizing the effect of oral administration of GW9662 during pregnancy on concentration-dependent dilation of uteroplacental arteries to SNP. *p < 0.05 vs. control.