Figure 2.

Treatment with sirolimus suppresses colonic damage in mice with induced colitis. Seventy-two hours following colitis induction, the histopathological tissue damage and the myeloperoxidase (MPO) activity were determined. (a) Colon sections from each experimental group were stained with haematoxylin & eosin (100 ×). (b) Microscopic score of each group. (c) MPO content was assessed in colonic tissue homogenates as described in Materials and methods. Data are presented as the mean ± SEM (n = 5 to n = 7 in each group). *P < 0·05 versus the PBS-treated group.