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. 2013 Jul 2;139(4):533–544. doi: 10.1111/imm.12106

Figure 5.

Figure 5

Epstein–Barr virus (EBV)-specific cultured ELISPOT responses following T-cell subset depletion. Peripheral blood mononuclear cells (PBMC), CD8-depleted PBMC and CD4-depleted PBMC from four EBV-seropositive healthy subjects were evaluated by cultured ELISPOT in response to peptide pools (15 amino acids in length with an 11-amino-acid overlap) representing the full-length lytic (BZLF1 and BMRF1) and latent (EBNA1, EBNA3a, EBNA3b, EBNA3c, LMP1 and LMP2) EBV proteins as well as to an EBV peptide pool (15 peptides, 8–10 amino acids in length) representing defined EBV-derived HLA class I-restricted T-cell epitopes. Results are shown as net spots/million PBMC. Box and whisker plots (Tukey) indicate median (middle line in the box) EBV-specific T-cell responses.