Table 2.
Crude and adjusted mean eGFR (ml/min/1.73m2) for each ETDRS retinopathy category overall and by diabetes status (N=1,936)
| Univariate Analysis |
Multivariate Analysis adjusted by traditional risk factors* |
Multivariate Analysis adjusted by traditional and non-traditional risk factors** |
||
|---|---|---|---|---|
| ETDRS retinopathy score | n | Mean eGFR (SE) | Mean eGFR (SE) | Mean eGFR (SE) |
| All participants (N=1936) | P<0.0001† | P<0.0001† | P=0.005† | |
| Normal | 1249 | 44.3 (0.44) | 43.8 (0.58) | 40.7 (0.61) |
| Very mild non-proliferative | 142 | 39.6 (1.29) | 40.2 (1.22) | 38.7 (1.15) |
| Non-proliferative | 243 | 36.4 (0.99) | 39.5 (1.03) | 38.5 (0.99) |
| Proliferative | 186 | 32.3 (1.14) | 36.7 (1.17) | 36.7 (1.13) |
| Ungradable | 116 | 36.0 (1.44) | 38.9 (1.37) | 39.1 (1.27) |
| Diabetic participants (N=925) | P<0.0001† | P<0.0001† | P=0.007† | |
| Normal | 389 | 42.8 (0.76) | 41.5 (0.93) | 39.2 (0.92) |
| Very mild non-proliferative | 67 | 39.3 (1.83) | 38.5 (1.77) | 37.8 (1.69) |
| Non-proliferative | 214 | 36.6 (1.03) | 37.5 (1.10) | 36.8 (1.07) |
| Proliferative | 175 | 32.2 (1.14) | 34.2 (1.22) | 34.4 (1.21) |
| Ungradable | 80 | 36.0 (1.69) | 37.2 (1.65) | 37.6 (1.56) |
| Non-diabetic participants (N=1011) | P<0.0001† | P=0.0008† | P=0.35† | |
| Normal | 860 | 45.1 (0.54) | 45.8 (0.72) | 42.2 (0.84) |
| Very mild non-proliferative | 75 | 40.0 (1.82) | 42.1 (1.66) | 40.1 (1.57) |
| Non-proliferative or worse | 40 | 35.1 (2.49) | 39.3 (2.32) | 39.7 (2.23) |
| Ungradable | 36 | 36.2 (2.62) | 39.6 (2.43) | 40.2 (2.21) |
*
Adjusted by age, race, systolic BP, diabetes (yes/no), and 24 hours urine protein. Diabetes was not included in the model for diabetic participants only or non-diabetic participants only.
**
Adjusted by age, race, systolic BP, diabetes (yes/no), 24 hours urine protein, anemia status (yes/no), use of angiotensin receptor blockers (yes/no), any cardio-vascular disease (yes/no), body mass index, cyclase-activating parathyroid hormone level, and smoking status (never/former/current).
†
For test assessing whether there is any statistically significant difference in eGFR among categories of ETDRS retinopathy score.