Table 4.
Multivariate analysis of ETDRS retinopathy features with eGFR (ml/min/1.73m2) for all participants
| Retinal features only without adjustment by other risk factors (n=1746)§ |
Adjustment by traditional risk factors* (n=1733)§ |
Adjustment by traditional and non- traditional risk factors** (n=1649)§ |
|
|---|---|---|---|
| ETDRS retinopathy features | Mean eGFR (SE) | Mean eGFR (SE) | Mean eGFR (SE) |
| Panretinal photocoagulation | P=0.002† | P=0.006† | P=0.09† |
| No | 32.5 (1.73) | 35.5 (1.64) | 34.5 (1.56) |
| Yes | 27.1 (2.28) | 31.2 (2.15) | 32.0 (2.03) |
| Retinal hemorrhage | P<0.0001† | P=0.002† | P=0.03† |
| None/Questionable | 33.8 (2.00) | 35.8 (1.88) | 34.8 (1.77) |
| 1 | 28.6 (2.42) | 31.8 (2.25) | 32.7 (2.13) |
| ≥2 | 27.0 (1.73) | 32.3 (1.70) | 32.1 (1.61) |
| Hard exudates | P=0.01† | P=0.06† | P=0.27† |
| None/Questionable | 32.6 (1.65) | 34.8 (1.56) | 33.9 (1.47) |
| <Standard 3 | 24.3 (3.15) | 29.2 (2.95) | 30.7 (2.78) |
| ≥ Standard 3 | 32.5 (2.13) | 35.9 (2.00) | 35.1 (1.90) |
| Intraretinal microvascular abnormality | P=0.0005† | P=0.0006† | P=0.0003† |
| None/Questionable | 34.7 (1.32) | 37.7 (1.29) | 37.5 (1.25) |
| Yes | 25.0 (2.98) | 29.0 (2.76) | 29.0 (2.58) |
*
Adjusted by age, race, systolic BP, diabetes (yes/no), and 24 hours urine protein.
**
Adjusted by age, race, systolic BP, diabetes (yes/no), 24 hours urine protein, anemia status (yes/no), use of angiotensin receptor blockers (yes/no), any cardio-vascular disease (yes/no), body mass index, cyclase-activating parathyroid hormone level, and smoking status (never/former/current).
§
Number of subjects included in the analysis after excluding the subjects with missing data in one or more predictors.
†
For test assessing whether there is any statistically significant difference in eGFR among categories of retinopathy features.