Table 1.
Effect of the alkaloids from Senna alata leaves on some abortifacient parameters of pregnant rats
| Parameters | Doses (mg/kg body weight) | |||
|---|---|---|---|---|
|
| ||||
| Controls | 250 | 500 | 1000 | |
| Number of implantation sites | 10.26±0.22 a | 6.78±0.43 b | 6.21±0.61 b | 6.28±0.95 b |
| Number of corpora lutea | 10.66±0.14 a | 7.62±0.69 b | 7.14±0.83 b | 7.22±1.03 b |
| Implantation index ( % ) | 91.74 | 88.98 | 86.97 | 86.98 |
| Pre- implantation losses ( % ) | 3.75 | 11.02 | 13.02 | 13.01 |
| Post- implantation loss ( % ) | 0 | 100 | 100 | 100 |
| Number of resorption sites | 0.00±0.00 a | 3.48±0.08 b | 4.05±0.09 c | 3.98±0.05 b |
| Resorption index ( % ) | 0 | 51.33 | 65.22 | 63.38 |
| *Weight of animal before pregnancy ( g ) | 144.00±3.28 a | 144.00±2.19 a | 142.50±3.83 a | 145.46±0.41 a |
| *Weight of animal after pregnancy (g) | 185.50±3.83 b | 166.00±3.89 c | 162.00±2.69 c | 167.33±1.03 c |
| Maternal weight gain ( % ) | 28.82 | 15.28 | 14.08 | 15.04 |
| Feed intake ( g/day per rat) | 20.32±0.75 a | 14.50±0.87 b | 15.33±0.47 b | 14.89±0.70 b |
| Water intake ( ml/day per rat) | 19.83±1.45 a | 16.63±0.75 b | 14.57±1.89 b | 11.99±1.83 c |
Values are expressed as mean±SD of six independent determinations;
a-d
Test values carrying superscripts different from the control for each parameter in the same row are significantly different (p < 0.05).
*
Maternal weights of the animals before pregnancy were compared with their corresponding weights after pregnancy for each treatment group (p < 0.05)