Table 3.
Effect of alkaloids from Senna alata leaves on some indices of oestrogenicity in pregnant rats
| Parameters | Doses (mg/kg body weight) | |||
|---|---|---|---|---|
|
| ||||
| Controls | 250 | 500 | 1000 | |
| Weight of uterus (g) | 1.80±0.21 a | 1.33±0.05 b | 1.53±0.05 c | 1.55±0.05 d |
| Uterine/body weight ratio (%) | 3.56±0.01 a | 1.44±0.29b | 0.87±0.05 c | 0.99±0.02c |
| Uterine alkaline phosphatase activity (nM/min/mg protein) | 1.51±0.02 a | 2.10±0.06 b | 2.19±0.14 b | 2.97±0.15 c |
| Uterine glucose concentration (mg/100 mg uterus) | 89.13±2.37 a | 65.89±4.02 b | 56.52±0.00 c | 41.30±2.38 d |
| Uterine cholesterol concentration (mmol/L) | 6.99±0.41 a | 4.36±0.70 b | 3.19±0.26 c | 2.20±0.00 d |
| Uterine protein content (mg/ml) | 275.50±1.64 a | 311.00±13.76 b | 398.50±10.69 c | 370.25±18.74 d |
Values are expressed as mean±SD of six independent determinations;
a-d
Test values carrying superscripts different from the control for each parameter in the same row are significantly different (p < 0.05)