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Frequent alterations of MAPK cascade genes in GC cell lines. A, schematic overview of novel exonic nonsynonymous SNVs in MAPK cascade genes in the cell lines. Blue, genes affected by “benign” SNVs; red, genes affected by “damaging” SNVs; red with underline, genes affected by nonsense substitutions. B, altered MAPK cascade genes in various GC cell lines. blue, Genes affected by “benign” SNVs; red, genes affected by either “damaging” missense substitutions or nonsense SNVs.
