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. Author manuscript; available in PMC: 2013 Jul 23.
Published in final edited form as: J Biomol NMR. 2008 Oct 2;42(3):197–207. doi: 10.1007/s10858-008-9272-0

Fig. 6.

Fig. 6

Details of the interaction between the inhibitor and the binding site of Grb2 SH2 domain. (a) pTyr+1 site; (b) pTyr+2 site; (c) pTyr+3 site. The inhibitors were shown as a stick model (cyan). Gln106, His107, Phe108, Lys109, Leu111 and Trp121 of Grb2 SH2 domain were shown as a stick model (green). Broken red lines in (b) indicated hydrogen bonds between the Hδ of Asn (pTyr+2) and Grb2 SH2 domain, as shown in the X-ray structure reported by Rahuel et al. (1996)