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Fyn deficiency promotes M-CSF-stimulated Lyn phosphorylation. WT and Fyn-/- BMMs cultured in M-CSF were cytokine- and serum-starved overnight. The cells were exposed to M-CSF (top) or RANKL (bottom) with time dictated by established signaling kinetics. Lyn immunoprecipitates were immunoblotted for total and phosphorylated Lyn. Blot intensity was densitometrically quantitated and the phospho-Lyn/total Lyn ratio normalized to time 0.
