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. Author manuscript; available in PMC: 2013 Jul 23.
Published in final edited form as: J Cell Biochem. 2010 Dec 1;111(5):1107–1113. doi: 10.1002/jcb.22841

Figure 3.

Figure 3

Absence of Fyn decreases bone resorption in vitro and in vivo. WT and Fyn-/- BMMs were cultured on bone with M-CSF and RANKL for 5 days. (A) Resorption lacuna formation was examined at day 5. (B) Resorptive activity was determined by collagen type I fragment (CTx) ELISA of culture media at day 5. (C, D) WT and Fyn-/- mice were injected, supracalvarially, with RANKL daily, for 7 days. (C) TRAP-stained (red reaction product) histological sections of calvariae. (D) Serum TRACP 5b levels at sacrifice were determined by ELISA. (*p< 0.05).