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. Author manuscript; available in PMC: 2013 Jul 23.
Published in final edited form as: Mol Cell Endocrinol. 2011 Aug 9;348(1):147–154. doi: 10.1016/j.mce.2011.08.001

Fig. 4.

Fig. 4

A functional link between the BMP system and GnRH-induced FSH transcription. BMP-6 and GnRH mutually augment FSHβ transcription in LβT2 cells. GnRH activates FSHβ transcription by activating the ERK pathway, which is negatively regulated by BMP-7. GnRH also provides a feedback inhibition of BMP-Smad signaling by suppressing Smad1/5/8, in part via increasing Smad6/7 expression, and reducing endogenous BMP-7 expression. There is a functional link between GnRH action and the BMP system for regulating FSHβ transcription in gonadotrope cells.