Table 2.
Baseline Characteristics and Treatment Contraindications for Hepatitis C Virus Among HCV- and HCV-HIV-Coinfected Subjects in Electronically Retrieved Cohort of HCV Infected Veterans
| HCV Only (n=27,452) | HCV and HIV coinfected (n=1225) | p-value | |
|---|---|---|---|
| Demographics | |||
| Mean (SD) age, years | 50.5 (7.8) | 48.6 (6.0) | <0.001 |
| Race | <0.001 | ||
| White | 46.4 | 23.8 | |
| Black | 23.9 | 53.3 | |
| Hispanic | 6.3 | 12.4 | |
| Other/unknown | 23.4 | 10.5 | |
| Gender (% male) | 96.8 | 98.4 | <0.001 |
| Liver biopsy performed | 1.9 | 1.8 | 0.4 |
| Referred to GI | 65.4 | 43.4 | <0.001 |
| Contraindicationsa | |||
| Anemia (Hb <12 for men, <11 for women) | 17.5 | 42.7 | <0.001 |
| Autoimmune disorders | 1.6 | 0.3 | <0.001 |
| Chronic obstructive pulmonary disease | 14.8 | 12.5 | 0.2 |
| Coronary artery disease | 12.0 | 7.9 | <0.001 |
| Decompensated liver disease | 14.4 | 26.4 | <0.001 |
| Neutropenia | 0.4 | 3.3 | <0.001 |
| Organ transplant | 1.0 | 0.2 | 0.005 |
| Active psychiatric disease | 6.5 | 9.5 | <0.001 |
| Recent alcohol use | 11.9 | 10.2 | 0.008 |
| Recent drug use | 6.3 | 13.4 | <0.001 |
| Renal failure (serum Cr >1.5) | 8.8 | 19.1 | <0.001 |
| Seizures | 4.9 | 5.6 | 0.003 |
| Uncontrolled diabetes | 8.0 | 7.8 | 0.1 |
a
Percentage of subjects with contraindications in the entire group.