FIG. 3.

Maitake D-Fraction induces apoptosis mediated by BAK1 stimulation and blocks tumor cells growth and proliferation in MCF-7 cells through activation of p27/Kip1 and RASSF2 genes. The putative molecular mechanism of apoptosis and anti-tumoral cell proliferation induced by Maitake D-Fraction in breast cancer MCF7 cells is shown, with red lines indicating stimulated pathways, green lines indicating inhibitory pathways, and discontinuous gray lines representing the genes whose expression has not been changed after Maitake treatment. Color images available online at www.liebertpub.com/jmf