FIG. 6.

Maitake D-fraction blocks malignant phenotype through activation of SPARC gene expression, and in collaboration with CUL3, they promote multi-drug sensitivity. The putative molecular mechanism of inhibition of malignant phenotype through activation of SPARC gene expression in MCF-7 cells is depicted. Also shown are the means by which SOD2 blocks the oxidative stress in tumoral cells and CUL3 participates in multi-drug sensitivity, blocking the output drug in those cells. Stimulated (red) and inhibitory (green) pathways are indicated. Discontinuous gray lines represent the genes whose expression has not been changed after Maitake treatment. Color images available online at www.liebertpub.com/jmf