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The biological activity of CH-01 is not associated with the bioreductive group. (a) Clonogenic assays were carried out using RKO cells exposed to DMSO, 25 μM inhibitor 6, 25 μM CH-EtOH 13 or 25 μM CH-01 1 for 24 h in either normoxia or hypoxia (≤0.02% O2). (b) The structure of compound 13, which ejects EtOH under hypoxic conditions.
