FIG. 2.

Finite element simulations demonstrate the ability to control the pressure distribution (a, b) and subsequent interstitial flow distribution within the device. In the first design the transverse pressure gradient across the microtissue chamber is variable (VP), or (ΔP₁>ΔP₁₂) while the mean pressure is constant (c). The alternate design creates equal (EQ) pressure gradients across the tissue microchambers (ΔP₁=ΔP₁₂), although the mean pressure of the chambers decreases as chamber number increases (d). Color images available online at www.liebertpub.com/tec