Western blot profiles of HIV-1 groups M, N, O, and P. The figure shows examples of Western blot reactivities with sera positive for the four groups. The group P-positive sample comes from the patient infected by the prototype strain RBF168. Of note, the group N-positive serum does not present a complete profile, due to advanced-stage disease (see reference 35 for complete profiles). The molecular masses of HIV-1 glycoproteins (gp) and proteins (p) are indicated in kDa.