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Schematic representation of B. burgdorferi BB0172 topology. We propose that BB0172 is anchored to the borrelial outer membrane through two TM segments located at the N terminus and C terminus of the protein and that the vWFA domain will be exposed to the exterior of the cell. The MIDAS motif is also present in the external segment of this protein, actively participating in the adhesion of BB0172 to α3β1 integrin.
