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Gene dosage-dependent role for β-arrestin-2 in preventing mortality following polymicrobial infection. Wild-type (WT), β-arrestin-2 homozygous knockout (β-arr2−/−), and β-arrestin-2 heterozygous (β-arr2+/−) mice were intraperitoneally injected with polymicrobial culture (40 × 106 CFU) in a 200-μl volume. Mice were then monitored for survival for 24 h. *, P value of <0.05 compared to the WT by a log-rank (Mantel Cox) test. n = 7 mice for each genotype.
