Fig 3.
Suppurative infections of the upper respiratory tract of FSP1-Cre;Cdc42fl/fl mice are prevented by antibiotic therapy. (A to D) Hematoxylin-eosin staining of FSP1-Cre;Cdc42fl/fl mice shows the absence of rhinitis (A, B) and otitis (C, D) following antibiotic administration. Depletion of lymphocytes and extramedullary granulopoiesis remain prominent in the spleen (E, F); granuolopoiesis is observed in the bone marrow (G), and severe lymphoid depletion is observed in the thymus (H). Magnifications, ×40 (A, C, and E) and ×400 (B, D, and F to H).