Table 4.
COG-based functional categories of ORFs identified as differences between M5-90 and the virulent B. melitensis strain M28a
| COG category | Function | No. of different ORFs | No. of OCDs |
|---|---|---|---|
| None | Not in COG database | 8 | 5 |
| C | Energy production and conversion | 3 | 1 |
| E | Amino acid transport and metabolism | 4 | 2 |
| G | Carbohydrate transport and metabolism | 1 | 1 |
| H | Coenzyme metabolism | 1 | 1 |
| I | Lipid metabolism | 1 | 0 |
| J | Translation, ribosomal structure, and biogenesis | 1 | 1 |
| L | DNA replication, recombination, and repair | 4 | 2 |
| M | Cell envelope biogenesis, outer membrane | 3 | 2 |
| O | Posttranslational modification, protein turnover, chaperones | 1 | 1 |
| P | Inorganic ion transport and metabolism | 1 | 0 |
| R | General function prediction only | 3 | 3 |
| S | Function unknown | 3 | 3 |
| U | Intracellular trafficking and secretion | 1 | 1 |
| Total | 35 | 23 |
a
Abbreviations: COG, clusters of orthologous groups (http://www.ncbi.nlm.nih.gov/COG/); OCDs, ORFs with consistent differences.