Table 4.
Outcome of category 2 cases (first-line retreatment regimen), by rpoB mutation detected at time of prime treatment failure or relapsea
| Mutations(s) in rpoB sequence | No. of episodes | Relapse-free cure |
FL and RLb |
|||
|---|---|---|---|---|---|---|
| n | % (95% CI)a | No. reported | % (95% CI)a | FL/RL ratio | ||
| 508Ile | 1 | 1 | 0 | |||
| 509Thr&526Leu | 1 | 1 | 0 | |||
| 511Arg&531Leu | 1 | 0 | 1 | Only FL | ||
| 511Pro | 21 | 3 | 14 | 15 | 71 | 1.1 |
| 511Pro&512Cys | 1 | 0 | 1 | Only FL | ||
| 511Pro&515Leu | 1 | 0 | 1 | Only FL | ||
| 511Pro&516Val | 1 | 0 | 1 | Only FL | ||
| 513Glu | 1 | 0 | 1 | Only FL | ||
| 513Lys | 3 | 1 | 1 | Only FL | ||
| 513Lys&526Asp | 1 | 0 | 0 | |||
| 513Pro | 1 | 0 | 1 | Only FL | ||
| 515Thr&516Gly | 2 | 1 | 1 | Only FL | ||
| 516Phe | 5 | 1 | 4 | 1.0 | ||
| 516Phe&531Leu | 1 | 0 | 0 | |||
| 516Tyr | 7 | 2 | 4 | Only FL | ||
| 516Val | 15 | 1 | 7 | 12 | 80 | 5.0 |
| 516Val&531Leu | 1 | 0 | 0 | |||
| 518Ser | 1 | 1 | 0 | |||
| 522Leu | 4 | 1 | 3 | Only FL | ||
| 523Glu | 1 | 1 | 0 | |||
| 526Arg | 7 | 2 | 6 | Only FL | ||
| 526Arg&531Glu | 1 | 0 | 1 | Only FL | ||
| 526Asn | 5 | 3 | 2 | Only FL | ||
| 526Asp | 17 | 4 | 24 | 8 | 47 | 1.0 |
| 526Cys | 2 | 0 | 2 | Only FL | ||
| 526Leu | 10 | 2 | 20 | 7 | 70 | 2.5 |
| 526Tyr | 31 | 9 | 29 | 19 | 61 | 18.0 |
| 531Leu | 159 | 27 | 17 | 101 | 64 | 6.0 |
| 531Trp | 6 | 1 | 5 | 4.0 | ||
| 533Pro | 20 | 7 | 35 | 12 | 60 | 1.4 |
| 535Ser | 1 | 1 | 0 | |||
| 536Ser | 1 | 1 | 0 | |||
| 572Phe | 5 | 2 | 2 | Only FL | ||
| DEL513_515 | 3 | 0 | 3 | 2.0 | ||
| INS512_513 | 3 | 0 | 3 | Only RL | ||
| INS513_514 | 3 | 1 | 2 | 1.0 | ||
| Any mutation | 345 | 74 | 21 (17.3–26.2) | 219 | 63 (58.1–68.5) | 4.2 |
| Disputed resistance | 70 | 19 | 27 (17.5–39.3) | 44 | 63 (50.4–73.9) | 2.4 |
| Undisputed resistance | 214 | 42 | 20 (14.7–25.7) | 134 | 63 (55.7–69.0) | 5.8 |
| Double mutations | 11 | 2 | 18 (3.2–52.2) | 6 | 55 (24.6–81.9) | Only FL |
| Unusual mutations | 5 | 5 | 0 | |||
a
Percentages are shown only if the denominator was at least 10.
b
FL, failure; RL, relapse.