Table 1.

Pooled MIC distributions of isavuconazole for Aspergillus spp. from two to eight laboratories, using the CLSI M38-A2 microdilution method^a

Species complex or section	No. of isolates/no. of laboratories	No. of isolates with MIC (μg/ml) of:
		0.03	0.06	0.125	0.25	0.5	1.0	2.0	4.0	≥8.0
A. fumigatus	855/8		6	31	149	508	113	33	4	11
A. flavus	444/7			2	29	253	146	13	1
A. nidulans	106/3		7	51	19	17	12
A. niger	207/6		1	4	11	52	75	55	7	2
A. terreus	384/4		4	32	171	162	14	1
A. versicolor	75/3	5	3	20	24	17	4	1		1
Aspergillus section Ustib	22/2				2		10	10

^aWild-type MIC distributions for each species were obtained by using the CLSI broth microdilution method (M38-A2) and according to the recently identified testing conditions for Aspergillus spp. and isavuconazole: 48 h of incubation and 100% growth inhibition (24, 25). Values in boldface type indicate modes or most frequent MICs for each species. The following are species complexes, as per nonmolecular identification (21): A. fumigatus, A. flavus, A. nidulans, A. niger, A. terreus, and A. versicolor.

^bAspergillus section Usti comprised the following species, as per molecular identification: A. calidoustus (17 isolates), A. pseudodeflectus (2 isolates), A. ustus (2 isolates), and A. insuetus (1 isolate) (22, 23; Peláez et al., unpublished).