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MTD and ED data for compounds 3n and 5 and l-glutamate of compound 2j compared to AMB (compound 1)a
| Compound | Dose (mg/kg/daily) |
ED/MTD (%) | |
|---|---|---|---|
| MTD | ED | ||
| 1 | 2.01 (1.88 ÷ 2.23) | 1.25 | 62 |
| l-Glutamate of 2j | 14.7 (12.8 ÷ 16.8) | 0.4 | 2.7 |
| 3n | 4.48 (4.23 ÷ 4.75) | 1.25 | 28 |
| 5 | 42.8 (41.2 ÷ 44.5) | 16.0 | 37.3 |
MTD, maximal tolerated dose; ED, effective dose that means elimination of 99% of infectious agent from kidneys.
