Table 1.
Library | No. of compounds screened | No. of hits |
Hit rate (%) | |||
---|---|---|---|---|---|---|
S | M | W | Total | |||
Asinex 1 | 12,378 | 1 | 12 | 13 | 0.11 | |
ChemBridge 3 | 8,448 | 5 | 42 | 47 | 0.56 | |
ChemDiv 3 | 11,968 | 1 | 3 | 1 | 5 | 0.04 |
ChemDiv 4 | 1,056 | 2 | 2 | 0.19 | ||
Enamine 2 | 26,224 | 2 | 25 | 148 | 175 | 0.67 |
Maybridge 5 | 3,212 | 2 | 2 | 0.06 | ||
Commercial total | 63,286 | 3 | 34 | 207 | 244 | 0.39 |
Strong (S) hits had >75% inhibition, while medium (M) hits had >50% inhibition and weak (W) hits had >25% inhibition of resazurin reduction in the presence of miconazole.