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Effect of AC17 with fluconazole in a guinea pig model of cutaneous candidiasis
| Test compound(s) | Dose(s) (%)c | Efficacy (%) | Mean tissue burden (log CFU/g tissue) ± SD |
|---|---|---|---|
| Fluconazole | 0.005 | 26.5 | 2.24 ± 1.11 |
| AC17 | 2 | 22.6 | 3.26 ± 0.52 |
| Fluconazole + AC17 | 0.005 + 2 | 60.8a,b | 1.49 ± 0.90a |
| Untreated control | NA | 3.58 ± 0.73 |
P value of <0.05 compared to the untreated control.
P value of <0.05 compared to fluconazole alone.
NA, not applicable.
