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Antitubercular activities of the indicated drugs in infected guinea pigs. Animals were infected via aerosol with ∼102 CFU of M. tuberculosis H37Rv and were either left untreated or treated with drugs daily (5 days/week) beginning 6 weeks after infection. R, rifampin at 100 mg/kg once daily; H, isoniazid at 60 mg/kg once daily; Z, pyrazinamide at 300 mg/kg once daily; Pa, PA-824 at 25 mg/kg twice daily (q8/16h); M, moxifloxacin at 90 mg/kg twice daily (q8/16h).
