Table 1.
Basic experimental scheme
| Groupa | No. of animals sacrificed at mob: |
|||||
|---|---|---|---|---|---|---|
| −1.5 | 0 | 0.5 | 1 (+3) | 2 (+3) | Total | |
| Untreated | 4 | 4 | 4 | 4 | 4 | 20 |
| R100H60Z300 | 4 | 4 (10) | 4 (10) | 12 (20) | ||
| Pa25 BID | 4 | 4 | 8 | |||
| M90 BID | 4 | 4 | 8 | |||
| Z300 | 4 | 4 | 8 | |||
| Pa25 BIDM90 BID | 4 | 4 | 8 | |||
| Pa25 BIDZ300 | 4 | 4 | 8 | |||
| M90 BIDZ300 | 4 | 4 | 8 | |||
| Pa25 BIDM90 BIDZ300 | 4 | 4 (10) | 4 (10) | 12 (20) | ||
| Total | 4 | 4 | 32 | 32 (20) | 8 (20) | 132 |
a
Drug doses (in mg/kg; single or twice-daily dose) are indicated by subscripts. BID, twice daily, every 16 and 8 h. Doses of each drug were determined to be human equivalent based on the AUC and were given orally daily (5 days/week).
b
Month −1.5, day after infection with M. tuberculosis; month 0, day of treatment initiation; month 0.5, 0.5 month after treatment initiation; and so on. “(+3)” indicates that the number of guinea pigs in parentheses was held for 3 months after treatment completion before sacrifice for relapse assessment.