Table 1.
Comparison of the groups' BUN, creatinine, and oxidative parametersa
| Parameter | Mean value ± SD for group |
P value |
||||
|---|---|---|---|---|---|---|
| G1 (control) | G2 (colistin) | G3 (colistin+GSPE) | G1 vs G2 | G1 vs G3 | G2 vs G3 | |
| BUN level (mg/dl) | 14.40 ± 1.80 | 25.78 ± 7.90 | 15.48 ± 2.84 | <0.05 | NS | <0.05 |
| Creatinine level (mg/dl) | 0.36 ± 0.02 | 0.56 ± 0.15 | 0.40 ± 0.04 | <0.05 | NS | <0.05 |
| TOS level (μmol H2O2 equivalents/g wet tissue) | 0.31 ± 0.45 | 0.41 ± 0.10 | 0.36 ± 0.42 | <0.05 | <0.05 | NS |
| TAS level (μmol Trolox equivalents/g wet tissue) | 24.23 ± 4.57 | 21.21 ± 3.41 | 23.32 ± 3.39 | NS | NS | NS |
| OSI | 1.30 ± 0.19 | 1.98 ± 0.43 | 1.56 ± 0.16 | <0.05 | <0.05 | <0.05 |
| MDA level (nmol/g wet tissue) | 78.48 ± 15.11 | 95.16 ± 13.82 | 70.84 ± 13.15 | <0.05 | NS | <0.05 |
a
Data are given as means ± standard deviations, and a P value of <0.05 was regarded as significant. Abbreviations: GSPE, grape seed proanthocyanidin extract; G1 group 1; G2, group 2; G3, group 3; BUN, blood urea nitrogen; TOS, total oxidant system; TAS, total antioxidant system; OSI, oxidative stress index [calculated as (TOS/TAS) × 100]; MDA, malondialdehyde; NS, not significant.