Fig 4.

Levels of transcription of hla, psmα, and RNAIII in MRSA strain USA300 exposed to 10 μg/ml (filled bars) or 50 μg/ml (open bars) of compounds. No gene expression was determined for compound VI at 50 μg/ml because growth inhibition prevented RNA isolation. Values are averages for three separate experiments; error bars indicate standard deviations. ***, P < 0.0005; **, P < 0.005; *, P < 0.05. (A) hla expression is displayed as log₂ of relative gene expression. (B) psmα expression is displayed as log₂ of relative gene expression. (C) RNAIII expression displayed as the fold change from the value with DMSO, which was set at 1. Values above 1 indicate an increase in expression, while values below 1 signify inhibition of expression. (D) spa expression is displayed as log₂ of relative gene expression.