Table 2.

Inhibitors of alpha-hemolysin formation and rabbit blood hemolysis by MRSA USA300

Compound	% Alpha-hemolysin inhibition as determined by ELISAa at:		% Inhibition of hemolysis of rabbit blood at:
	1 μg/ml	10 μg/ml	1 μg/ml	10 μg/ml
I	28.0 ± 4.4	65.0 ± 2.5	NDb	ND
II	21.3 ± 5.2	76.0 ± 1.2	42.0 ± 2.8	69.9 ± 6.1
III	20.8 ± 3.5	28.3 ± 3.4	ND	ND
IV	40.2 ± 5.2	73.6 ± 2.2	ND	ND
V	23.0 ± 1.3	88.4 ± 1.5	9.0 ± 1.3	63.6 ± 6.6
VI	55.2 ± 5.8	76.3 ± 11.2	9.2 ± 0.7	97.9 ± 9.3
VII	31.3 ± 9.0	61.0 ± 14.8	38.6 ± 6.4	55.6 ± 9.3
VIII	15.9 ± 4.2	41.9 ± 8.2	6.0 ± 7.5	21.3 ± 6.1
IX	33.0 ± 3.6	62.3 ± 1.8	63.0 ± 1.9	97.7 ± 4.2
X	49.4 ± 4.6	53.0 ± 5.9	34.3 ± 6.9	84.7 ± 6.7
XI	0.0 ± 7.0	68.8 ± 11.3	49.0 ± 2.2	76.6 ± 8.1

^aELISAs were carried out in 2% DMSO as the solvent. Control measurements with this solvent were arbitrarily assigned values of 0% inhibition and 100% bacterial growth. All other data were normalized to the control solvent data.

^bND, not determined.