Table 2.
Statistical comparisons of midazolam and 1-hydroxy midazolam pharmacokinetic parametersa
| Pharmacokinetic parameters | Geometric LS mean (n) |
% GMR | 90% CI | |
|---|---|---|---|---|
| Treatment A (reference): midazolam alone | Treatment B (test): midazolam + PA-824 | |||
| Midazolam | ||||
| Cmax (ng/ml) | 10.82 (14) | 9.05 (14) | 83.63 | 75.11–93.11 |
| AUC0–t (ng · h/ml) | 27.63 (14) | 23.38 (14) | 84.61 | 74.21–96.47 |
| AUC0–∞ (ng · h/ml) | 28.97 (13) | 24.47 (13) | 84.45 | 73.79–96.64 |
| 1-Hydroxy midazolam | ||||
| Cmax (ng/ml) | 4.76 (14) | 5.00 (14) | 105.23 | 93.13–118.9 |
| AUC0–t (ng · h/ml) | 10.86 (14) | 12.38 (14) | 113.98 | 105.53–123.09 |
| AUC0–∞ (ng · h/ml) | 11.57 (10) | 13.04 (10) | 112.68 | 103.07–123.18 |
a
n, number of subjects contributing data; Cmax, maximum observed concentration; AUC0–t, area under the concentration-time curve during the dosing interval; AUC0–∞, area under the concentration-time curve extrapolated to infinity; LS mean, least-squares mean; GMR, geometric mean ratio; CI, confidence interval.