Fig 1.

Identification of peptides with potent antimicrobial activity against N. meningitidis. N. meningitidis serogroup C strain FAM20 cells (10⁵ CFU/ml) were incubated for 6 h with CPPs, LL-37, or polymyxin B (PMB) at a concentration of 30 μM in PBS or with PBS alone (control) in GC broth. LL-37 was suspended to 30 μM in 0.1% TFA. Treatment with 0.1% TFA alone (for LL-37) gave results equal to those with PBS alone (control). CFU were determined by plating of serial dilutions. Data are presented as means and standard deviations of ≥2 independent experiments. Peptides are listed in Table 1.