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HIV-LucTG mice express hCCR5 and hCD4. (A) Construct used to produce transgenic mice expressing hCCR5 and hCD4 under the control of the human ubiquitin C (UbC) promoter. SV40, simian virus 40; BGH, bovine growth hormone. (B) Representative fluorescence-activated cell sorter analysis of hCCR5 and hCD4 expression on PBMCs of an HIV-LucTG mouse, a transgene-negative littermate, and a human healthy control.
