Fig 1.

Replication fitness of multiple NNRTI-resistant HIV-1 variants in the presence of ETV or NVP. (A) Concentrations of p24 in culture supernatant from cells infected with pooled virus and exposed to different concentrations of ETV or NVP. (B, C, D, E, F, and G) The relative prevalences of 12 viruses each containing a single resistance mutation as determined by longitudinal deep sequencing of viral RNA from culture supernatant from cells infected with pooled virus and exposed to no drug (control), 20 nM ETV, 200 nM ETV, 500 nM ETV, or 5 μM NVP.