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Susceptibility to ETV and NVP of selected NNRTI-resistant HIV-1 viruses
| NNRTI parameter | Valuea |
|||||||
|---|---|---|---|---|---|---|---|---|
| WT | K101P | K103N | E138A | Y181C | Y181I | Y181V | G190S | |
| ETV | ||||||||
| EC50 (nM) | 5.7 | 27.8 | 3.8 | 15.9 | 44.3 | 353 | 328 | 2.2 |
| Fold R | 4.9 | 0.7 | 2.8 | 7.8 | 61.9 | 57.9 | 0.4 | |
| NVP | ||||||||
| EC50 (μM) | 0.28 | >20 | >20 | 0.23 | >20 | >20 | >20 | >20 |
| Fold R | >50 | >50 | 0.8 | >50 | >50 | >50 | >50 | |
EC50 values represent mean values from at least 3 independent experiments. Fold R values represent mean fold change in EC50 of mutant versus WT virus.
