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. Author manuscript; available in PMC: 2013 Jul 23.
Published in final edited form as: Neuroreport. 2011 Aug 24;22(12):623–627. doi: 10.1097/WNR.0b013e3283497334

Fig. 1.

Fig. 1

βAPP, Aβ42, and complement factor H (CFH) levels in transgenic murine models of Alzheimer’s disease (Tg-AD) mouse retina compared with the age-matched controls. The presence of βAPP and Aβ42 peptides suggests a common and functional secretase-mediated processing of βAPP in the Tg-AD retina [8,12,13]; other βAPP-derived peptide fragments in Tg-AD retina have been described [13]. As further discussed in the text, highest relative βAPP, Aβ42, and the lowest relative CFH levels were found in 5xFAD retina. A dashed horizontal line at 5.0 indicates relative CFH levels in PSAPP mice for ease of comparison; N=5; *P<0.05; **P<0.01 (analysis of variance).