Table 2.
Aβ40, Aβ42, and Aβ40 and Aβ42 peptide levels in human and transgenic murine models of Alzheimer’s disease brain and retina
| Tissue | N | Aβ40 peptide (pmol/g protein) | Aβ42 peptide (pmol/g protein) | Aβ40 and Aβ42 (pmol/g protein) |
|---|---|---|---|---|
| Human control neocortex | 6 | 22.4 ±9.4 | 56.3 ±11.5 | 78.7 |
| Human AD neocortex | 6 | 144.5 ±66.8* | 1529 ±222** | 2073.5** |
| Human AD retina | 3 | 11.5 ±1.1 | 201.4 ±112* | 212.9* |
| C57BL6 control brain | 3 | 1.25 ±0.7 | 1.51 ±0.8 | 2.76 |
| C57BL6/SJL control brain | 3 | 2.13 ±1.1 | 14.15 ±2.01 | 16.28 |
| C57Bl6/SJL control retina | 3 | 1.05 ±0.8 | 2.45 ±4.51 | 3.5 |
| Tg2576 brain | 5 | 263 ±563* | 1200 ±234** | 1463* |
| PSAPP brain | 5 | 767 ±321** | 1534 ±450** | 2301** |
| 3xTg-AD brain | 5 | 817 ±224** | 1384 ±158** | 2201** |
| 5xFAD brain | 5 | 861 ±451** | 1966 ±328** | 2827** |
| Tg2576 retina | 4 | 1.26 ±0.8 | 85 ±39* | 86.26* |
| PSAPP retina | 3 | 1.61 ±1.1* | 18.2 ±1.8* | 19.82* |
| 3xTg-AD retina | 5 | 1.22 ±0.2 | 33.1 ±16.1* | 34.22* |
| 5xFAD retina | 6 | 3.6 ±1.5** | 181 ±112** | 184.6** |
Age-matched control retinal tissues from transgenic murine models of Alzheimer’s disease (Tg-AD) mice showed Aβ40 or Aβ42 of less than 1 pmol/g of tissue (below the detection limit of the enzyme-linked immunosorbent assay of 1 pmol/g of protein) [21]; statistical analysis of Aβ40 and Aβ42 peptide includes the mean pmol/g of protein for the N (number analyzed) for each tissue, and one standard deviation from that mean; the combined Aβ40 and Aβ42 peptide abundance (right-most column) is an arithmetic sum of individual Aβ40 and Aβ42 peptide mean abundances.
*
P<0.05. Significance over-respective controls are indicated.