. Author manuscript; available in PMC: 2014 May 13.

Published in final edited form as: JAMA Intern Med. 2013 May 13;173(9):763–769. doi: 10.1001/jamainternmed.2013.116

Table 3.

Association of high-sensitivity troponin T (per doubling) with cardiovascular events after adjusting for clinical risk factors and measures of disease severity.

	Myocardial Infarction		Heart Failure		Cardiovascular Death		Any Event
	HR (95%CI)^a	P-value	HR (95%CI)^a	P-value	HR (95%CI)^a	P-value	HR (95%CI)^a	P-value

Unadjusted	1.74 (1.50, 2.03)	<.001	2.30 (2.04, 2.59)	<.001	1.95 (1.70, 2.23)	<.001	1.98 (1.80, 2.17)	<.001
Model 1^b	1.55 (1.26, 1.91)	<.001	1.92 (1.62, 2.28)	<.001	1.78 (1.46, 2.16)	<.001	1.68 (1.47, 1.92)	<.001
Model 2^c	1.32 (1.02, 1.71)	0.03	1.55 (1.19, 2.01)	0.001	1.39 (1.06, 1.83)	0.02	1.42 (1.19, 1.70)	<.001
Model 3^d	1.28 (0.99, 1.67)	0.06	1.44 (1.10, 1.89)	0.007	1.36 (1.03, 1.81)	0.03	1.37 (1.14, 1.65)	0.001

Hazard Ratio (HR) for cardiovascular events per doubling in high-sensitivity troponin T.

Model 1 - Adjusted for age, male sex, smoking, history of hypertension, history of heart failure, history of diabetes mellitus, revascularization, physical inactivity, systolic blood pressure, diastolic blood pressure, estimated glomerular filtration rate, ace-inhibitor or angiotensin receptor blocker use, statin use, diuretic use.

Model 2 - Adjusted for Model 1 plus left ventricular mass index, left ventricular ejection fraction, left atrial function index, diastolic dysfunction, inducible ischemia, treadmill exercise capacity.

Model 3 - Adjusted for Model 2 plus natural logarithm of NT-proBNP, natural logarithm of C-reactive protein.